Iron in PDB 4zhk: Crystal Structure of RPE65 in Complex with Mb-002

All present enzymatic activity of Crystal Structure of RPE65 in Complex with Mb-002:
3.1.1.64;

The structure of Crystal Structure of RPE65 in Complex with Mb-002, PDB code: 4zhk was solved by P.D.Kiser, K.Palczewski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.85 / 2.09
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	175.668, 175.668, 86.297, 90.00, 90.00, 120.00
R / Rfree (%)	17.2 / 20.5

The structure of Crystal Structure of RPE65 in Complex with Mb-002 also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Iron atom in the Crystal Structure of RPE65 in Complex with Mb-002 (pdb code 4zhk). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of RPE65 in Complex with Mb-002, PDB code: 4zhk:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Crystal Structure of RPE65 in Complex with Mb-002


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of RPE65 in Complex with Mb-002 within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe601 b:29.4 occ:1.00 O A:A9V607 2.2 47.7 1.0 NE2 A:HIS527 2.2 27.4 1.0 NE2 A:HIS180 2.2 26.6 1.0 NE2 A:HIS313 2.3 26.0 1.0 NE2 A:HIS241 2.3 25.8 1.0 CE1 A:HIS527 3.0 28.4 1.0 CD2 A:HIS313 3.1 27.3 1.0 CE1 A:HIS180 3.1 27.6 1.0 CD2 A:HIS527 3.2 27.5 1.0 C A:A9V607 3.3 44.3 1.0 CE1 A:HIS241 3.3 24.9 1.0 CD2 A:HIS180 3.3 27.7 1.0 CD2 A:HIS241 3.3 24.6 1.0 CE1 A:HIS313 3.3 27.8 1.0 C1 A:A9V607 3.7 48.4 1.0 O1 A:A9V607 3.8 43.4 1.0 ND1 A:HIS527 4.1 27.1 1.0 CG A:HIS527 4.2 27.9 1.0 ND1 A:HIS180 4.3 28.3 1.0 CG A:HIS313 4.3 26.9 1.0 ND1 A:HIS313 4.4 28.9 1.0 CG A:HIS180 4.4 29.0 1.0 ND1 A:HIS241 4.4 26.3 1.0 C2 A:A9V607 4.4 50.1 1.0 CG A:HIS241 4.4 24.7 1.0 CG1 A:VAL134 4.7 30.3 1.0

Iron binding site 2 out of 2 in the Crystal Structure of RPE65 in Complex with Mb-002


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of RPE65 in Complex with Mb-002 within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe601 b:27.2 occ:1.00 O B:A9V606 2.1 41.8 1.0 NE2 B:HIS527 2.2 26.3 1.0 NE2 B:HIS180 2.2 27.8 1.0 NE2 B:HIS313 2.3 27.3 1.0 NE2 B:HIS241 2.3 24.8 1.0 CE1 B:HIS527 3.1 26.8 1.0 CD2 B:HIS313 3.1 28.4 1.0 CE1 B:HIS180 3.1 27.5 1.0 CD2 B:HIS527 3.2 26.5 1.0 CE1 B:HIS241 3.3 25.1 1.0 CD2 B:HIS241 3.3 23.9 1.0 CD2 B:HIS180 3.3 27.0 1.0 CE1 B:HIS313 3.3 25.5 1.0 C B:A9V606 3.4 41.8 1.0 O1 B:A9V606 3.8 42.8 1.0 C1 B:A9V606 3.9 45.7 1.0 ND1 B:HIS527 4.1 26.6 1.0 CG B:HIS527 4.2 26.1 1.0 ND1 B:HIS180 4.3 27.9 1.0 CG B:HIS313 4.3 27.4 1.0 ND1 B:HIS313 4.4 27.2 1.0 CG B:HIS180 4.4 28.6 1.0 ND1 B:HIS241 4.4 26.5 1.0 CG B:HIS241 4.4 24.3 1.0 C2 B:A9V606 4.6 46.8 1.0 CG1 B:VAL134 4.7 31.5 1.0

P.D.Kiser, K.Palczewski. Crystal Structure of RPE65 in Complex with Mb-002 To Be Published.