Iron in PDB 6e35: Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160

Enzymatic activity of Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160

All present enzymatic activity of Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160:
1.13.11.52;

Protein crystallography data

The structure of Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160, PDB code: 6e35 was solved by F.Forouhar, A.Lewis-Ballester, S.Lew, S.Karkashon, J.Seetharaman, C.Lu, M.Hussain, S.-R.Yeh, L.Tong, Northeast Structural Genomics Consortium(Nesg), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.70 / 2.41
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 85.770, 90.302, 136.766, 90.00, 90.00, 90.00
R / Rfree (%) 18.2 / 23.6

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160 (pdb code 6e35). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160, PDB code: 6e35:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 6e35

Go back to Iron Binding Sites List in 6e35
Iron binding site 1 out of 2 in the Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe501

b:39.6
occ:1.00
 FE A:HEM501 0.0 39.6 1.0
C A:CYN502 1.8 31.2 1.0
NC A:HEM501 2.0 39.8 1.0
NB A:HEM501 2.1 37.9 1.0
NA A:HEM501 2.1 35.5 1.0
ND A:HEM501 2.1 35.5 1.0
NE2 A:HIS346 2.2 27.8 1.0
N A:CYN502 2.9 32.4 1.0
C1B A:HEM501 3.0 35.5 1.0
C4A A:HEM501 3.0 38.0 1.0
C1C A:HEM501 3.1 39.1 1.0
C4B A:HEM501 3.1 41.9 1.0
C4C A:HEM501 3.1 40.8 1.0
CE1 A:HIS346 3.1 31.5 1.0
C1D A:HEM501 3.1 39.6 1.0
C1A A:HEM501 3.2 34.5 1.0
C4D A:HEM501 3.2 34.8 1.0
CD2 A:HIS346 3.2 35.3 1.0
CHB A:HEM501 3.4 34.3 1.0
CHC A:HEM501 3.5 39.0 1.0
CHD A:HEM501 3.5 34.2 1.0
CHA A:HEM501 3.7 33.6 1.0
C2B A:HEM501 4.3 35.4 1.0
ND1 A:HIS346 4.3 30.8 1.0
C2C A:HEM501 4.3 40.9 1.0
C3A A:HEM501 4.3 37.7 1.0
C3B A:HEM501 4.3 38.4 1.0
C3C A:HEM501 4.3 39.8 1.0
C2A A:HEM501 4.3 33.4 1.0
C2D A:HEM501 4.3 43.3 1.0
CG A:HIS346 4.4 28.0 1.0
C3D A:HEM501 4.4 40.3 1.0
CD1 A:TRP503 4.8 43.5 1.0

Iron binding site 2 out of 2 in 6e35

Go back to Iron Binding Sites List in 6e35
Iron binding site 2 out of 2 in the Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe501

b:39.5
occ:1.00
 FE B:HEM501 0.0 39.5 1.0
C B:CYN502 1.8 39.0 1.0
NB B:HEM501 1.9 36.4 1.0
NC B:HEM501 2.1 38.7 1.0
NA B:HEM501 2.1 38.2 1.0
ND B:HEM501 2.2 37.6 1.0
NE2 B:HIS346 2.2 36.5 1.0
N B:CYN502 2.9 31.1 1.0
CE1 B:HIS346 3.0 34.1 1.0
C1B B:HEM501 3.0 37.1 1.0
C4A B:HEM501 3.0 33.9 1.0
C4B B:HEM501 3.0 36.9 1.0
C1C B:HEM501 3.1 40.0 1.0
C1D B:HEM501 3.1 39.4 1.0
C4C B:HEM501 3.1 37.3 1.0
C1A B:HEM501 3.2 36.8 1.0
C4D B:HEM501 3.3 37.0 1.0
CHB B:HEM501 3.3 44.5 1.0
CD2 B:HIS346 3.4 40.3 1.0
CHC B:HEM501 3.4 32.2 1.0
CHD B:HEM501 3.5 35.9 1.0
CHA B:HEM501 3.7 39.9 1.0
ND1 B:HIS346 4.2 41.6 1.0
C2B B:HEM501 4.2 36.0 1.0
C3B B:HEM501 4.2 37.4 1.0
C3A B:HEM501 4.2 36.7 1.0
C2C B:HEM501 4.3 45.5 1.0
C2A B:HEM501 4.3 34.4 1.0
C3C B:HEM501 4.3 37.1 1.0
C2D B:HEM501 4.4 39.6 1.0
CG B:HIS346 4.4 41.5 1.0
C3D B:HEM501 4.4 34.1 1.0
CD1 B:TRP503 4.6 40.7 1.0
NE1 B:TRP503 4.9 37.1 1.0

Reference:

F.Forouhar, A.Lewis-Ballester, S.Lew, S.Karkashon, J.Seetharaman, C.Lu, M.Hussain, S.-R.Yeh, L.Tong. Crystal Structure of Human Indoleamime 2,3-Dioxygenase (IDO1) in Complex with L-Trp and Cyanide, Northeast Structural Genomics Target HR6160 To Be Published.
Page generated: Sun Dec 13 16:24:46 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy