Iron in PDB 8b43: Crystal Structure of Ferrioxamine Transporter

The structure of Crystal Structure of Ferrioxamine Transporter, PDB code: 8b43 was solved by I.Josts, H.Tidow, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	59.33 / 2.49
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	95.411, 95.411, 177.984, 90, 90, 120
R / Rfree (%)	21.7 / 25.9

The binding sites of Iron atom in the Crystal Structure of Ferrioxamine Transporter (pdb code 8b43). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Ferrioxamine Transporter, PDB code: 8b43:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Crystal Structure of Ferrioxamine Transporter


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Ferrioxamine Transporter within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe907 b:43.8 occ:1.00 O27 A:OX8910 1.9 57.1 1.0 O28 A:OX8910 1.9 59.9 1.0 O23 A:OX8910 2.0 45.9 1.0 O23 A:OX8911 2.1 58.5 1.0 O27 A:OX8911 2.2 47.9 1.0 O10 A:OX8910 2.4 46.2 1.0 N24 A:OX8910 2.5 52.9 1.0 C22 A:OX8910 2.6 46.4 1.0 C22 A:OX8911 2.8 50.5 1.0 N11 A:OX8910 2.8 52.4 1.0 N24 A:OX8911 2.9 50.4 1.0 C09 A:OX8910 3.0 46.5 1.0 C25 A:OX8910 3.9 61.0 1.0 C21 A:OX8910 4.1 50.8 1.0 C12 A:OX8911 4.1 61.1 1.0 C12 A:OX8910 4.2 56.0 1.0 C01 A:OX8910 4.2 49.0 1.0 C21 A:OX8911 4.2 43.3 1.0 C25 A:OX8911 4.3 49.2 1.0 CE1 A:PHE246 4.3 52.8 1.0 C14 A:OX8910 4.4 53.7 1.0 CE1 A:HIS374 4.5 46.2 1.0 C08 A:OX8910 4.5 51.7 1.0 N04 A:OX8911 4.5 67.7 1.0 C20 A:OX8911 4.6 45.5 1.0 N04 A:OX8910 4.6 53.8 1.0 C20 A:OX8910 4.6 46.8 1.0 C26 A:OX8910 4.7 58.6 1.0 C13 A:OX8910 4.7 55.2 1.0 N11 A:OX8911 4.9 74.8 1.0 C18 A:OX8910 4.9 54.6 1.0 C07 A:OX8911 5.0 61.4 1.0 CZ A:PHE246 5.0 44.4 1.0 N17 A:OX8910 5.0 58.5 1.0 C08 A:OX8911 5.0 61.1 1.0

Iron binding site 2 out of 2 in the Crystal Structure of Ferrioxamine Transporter


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Ferrioxamine Transporter within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe908 b:70.8 occ:1.00 O10 A:OX8909 2.0 98.4 1.0 O28 A:OX8911 2.1 92.9 1.0 O27 A:OX8909 2.1 97.4 1.0 O23 A:OX8909 2.4 77.3 1.0 O28 A:OX8909 2.5 98.9 1.0 O10 A:OX8911 2.6 85.8 1.0 N24 A:OX8909 2.7 94.3 1.0 N11 A:OX8911 2.7 74.8 1.0 C09 A:OX8909 2.7 98.2 1.0 C22 A:OX8909 2.8 85.3 1.0 C09 A:OX8911 2.9 74.9 1.0 N11 A:OX8909 3.0 100.1 1.0 C12 A:OX8911 3.9 61.1 1.0 C25 A:OX8909 4.0 81.5 1.0 C13 A:OX8911 4.1 61.0 1.0 C08 A:OX8909 4.2 100.3 1.0 C21 A:OX8909 4.2 87.0 1.0 C08 A:OX8911 4.3 61.1 1.0 C12 A:OX8909 4.4 86.6 1.0 C14 A:OX8911 4.6 50.5 1.0 C07 A:OX8909 4.6 85.4 1.0 C26 A:OX8909 5.0 67.9 1.0 OH A:TYR799 5.0 108.8 1.0 C05 A:OX8909 5.0 83.4 1.0 N17 A:OX8909 5.0 91.1 1.0

D.C.K.Chan, I.Josts, K.Koteva, G.D.Wright, H.Tidow, L.L.Burrows. Interactions of Tonb-Dependent Transporter Foxa with Siderophores and Antibiotics That Affect Binding, Uptake, and Signal Transduction. Proc.Natl.Acad.Sci.Usa V. 120 53120 2023.
ISSN: ESSN 1091-6490
PubMed: 37043535
DOI: 10.1073/PNAS.2221253120