Iron in PDB 8rmc: Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation)

All present enzymatic activity of Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation):
2.8.1.7;

The binding sites of Iron atom in the Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation) (pdb code 8rmc). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation), PDB code: 8rmc:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe201 b:49.7 occ:1.00 OD2 D:ASP71 2.1 19.7 1.0 SG A:CYS381 2.3 22.1 1.0 SG D:CYS95 2.3 21.7 1.0 NE2 D:HIS137 2.3 14.2 1.0 CG D:ASP71 2.9 16.6 1.0 OD1 D:ASP71 3.1 23.1 1.0 CE1 D:HIS137 3.3 7.2 1.0 CD2 D:HIS137 3.4 10.5 1.0 CB A:CYS381 3.4 11.0 1.0 CB D:CYS95 3.5 4.9 1.0 SG D:CYS138 3.9 17.1 1.0 N D:CYS95 4.1 7.2 1.0 SG D:CYS69 4.1 34.0 1.0 CB D:ASP71 4.3 14.4 1.0 CA D:CYS95 4.4 3.3 1.0 ND1 D:HIS137 4.4 8.5 1.0 NZ D:LYS135 4.4 18.1 1.0 CG D:HIS137 4.5 13.2 1.0 CA A:CYS381 4.6 10.2 1.0 CB D:ALA98 4.7 3.8 1.0

Iron binding site 2 out of 4 in the Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ I:Fe201 b:26.1 occ:1.00 FE1 I:FES201 0.0 26.1 1.0 S2 I:FES201 2.2 20.3 1.0 S1 I:FES201 2.2 20.5 1.0 SG I:CYS114 2.3 12.3 1.0 SG I:CYS108 2.3 16.5 1.0 FE2 I:FES201 3.1 24.1 1.0 CB I:CYS114 3.4 5.0 1.0 N I:CYS114 3.4 5.8 1.0 CB I:CYS108 3.5 8.2 1.0 N I:CYS108 3.8 9.4 1.0 N I:SER115 3.8 2.7 1.0 CA I:CYS114 3.8 4.0 1.0 CA I:CYS108 4.1 10.3 1.0 N I:ALA113 4.1 12.4 1.0 C I:CYS114 4.3 2.9 1.0 N I:LEU112 4.4 10.1 1.0 C I:CYS108 4.4 13.3 1.0 N I:GLU109 4.5 50.7 1.0 C I:ALA113 4.5 7.5 1.0 N I:ALA110 4.5 19.4 1.0 N I:THR116 4.6 2.9 1.0 N I:SER111 4.7 16.3 1.0 N I:ALA107 4.7 13.7 1.0 CA I:LEU112 4.7 10.5 1.0 CA I:SER115 4.8 5.6 1.0 OG1 I:THR116 4.8 13.4 1.0 SG I:CYS117 4.8 4.5 1.0 CA I:ALA113 4.9 8.0 1.0 C I:GLY106 4.9 15.3 1.0 SG I:CYS154 4.9 19.1 1.0 C I:LEU112 4.9 7.1 1.0 C I:ALA107 5.0 14.4 1.0

Iron binding site 3 out of 4 in the Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ I:Fe201 b:24.1 occ:1.00 FE2 I:FES201 0.0 24.1 1.0 S1 I:FES201 2.2 20.5 1.0 S2 I:FES201 2.2 20.3 1.0 SG I:CYS117 2.3 4.5 1.0 SG I:CYS154 2.3 19.1 1.0 CB I:CYS154 3.0 4.9 1.0 FE1 I:FES201 3.1 26.1 1.0 CB I:CYS117 3.4 3.3 1.0 CA I:CYS154 4.2 8.1 1.0 N I:CYS154 4.2 6.4 1.0 CA I:ALA110 4.4 15.3 1.0 N I:CYS117 4.4 3.4 1.0 CA I:CYS117 4.5 2.1 1.0 N I:ALA110 4.5 19.4 1.0 SG I:CYS114 4.6 12.3 1.0 CB I:LEU152 4.7 5.2 1.0 SG I:CYS108 4.7 16.5 1.0 CD1 I:LEU152 4.8 10.0 1.0 N I:LEU112 4.8 10.1 1.0 CD2 I:LEU152 5.0 3.8 1.0

Iron binding site 4 out of 4 in the Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Structure of the FDX2-Bound Core Isc Complex (Proximal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ H:Fe201 b:106.4 occ:1.00 OD2 H:ASP71 2.1 17.2 1.0 SG E:CYS381 2.3 37.7 1.0 SG H:CYS95 2.3 24.2 1.0 NE2 H:HIS137 2.4 21.7 1.0 CG H:ASP71 2.9 15.7 1.0 OD1 H:ASP71 3.0 22.1 1.0 CE1 H:HIS137 3.3 17.6 1.0 CD2 H:HIS137 3.4 21.1 1.0 CB H:CYS95 3.5 5.9 1.0 CB E:CYS381 3.5 34.2 1.0 SG H:CYS69 3.9 47.4 1.0 SG H:CYS138 4.0 19.1 1.0 N H:CYS95 4.0 4.9 1.0 CB H:ASP71 4.3 9.8 1.0 CA H:CYS95 4.4 2.9 1.0 ND1 H:HIS137 4.5 19.5 1.0 CG H:HIS137 4.5 22.4 1.0 NZ H:LYS135 4.6 17.3 1.0 CA E:CYS381 4.7 35.1 1.0 CB H:ALA98 4.7 5.8 1.0 CB H:CYS69 5.0 47.6 1.0

R.Steinhilper, L.Boss, S.A.Freibert, V.Schulz, N.Krapoth, S.Kaltwasser, R.Lill, B.J.Murphy. Two-Stage Binding of Mitochondrial Ferredoxin-2 to the Core Iron-Sulfur Cluster Assembly Complex. Nat Commun V. 15 10559 2024.
ISSN: ESSN 2041-1723
PubMed: 39632806
DOI: 10.1038/S41467-024-54585-4