Iron in PDB 8rmf: Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation)

All present enzymatic activity of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation):
2.8.1.7;

The binding sites of Iron atom in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation) (pdb code 8rmf). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation), PDB code: 8rmf:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe201 b:98.6 occ:1.00 OD2 D:ASP71 2.1 64.6 1.0 NE2 D:HIS137 2.3 60.1 1.0 SG D:CYS95 2.3 64.3 1.0 SG A:CYS381 2.3 75.6 1.0 CG D:ASP71 3.0 57.9 1.0 CE1 D:HIS137 3.2 59.8 1.0 OD1 D:ASP71 3.3 63.5 1.0 CD2 D:HIS137 3.4 60.8 1.0 CB A:CYS381 3.5 63.8 1.0 CB D:CYS95 3.6 49.5 1.0 SG D:CYS138 3.8 62.1 1.0 SG D:CYS69 3.9 69.1 1.0 N D:CYS95 4.3 52.6 1.0 ND1 D:HIS137 4.3 61.6 1.0 CB D:ASP71 4.4 52.5 1.0 CG D:HIS137 4.5 59.9 1.0 CA D:CYS95 4.6 47.3 1.0 NZ D:LYS135 4.6 58.5 1.0 CA A:CYS381 4.6 64.1 1.0 CB D:ALA98 4.8 42.3 1.0

Iron binding site 2 out of 4 in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ I:Fe201 b:60.6 occ:1.00 FE1 I:FES201 0.0 60.6 1.0 S2 I:FES201 2.2 44.0 1.0 S1 I:FES201 2.2 43.8 1.0 SG I:CYS108 2.3 64.3 1.0 SG I:CYS114 2.3 51.7 1.0 FE2 I:FES201 3.1 63.3 1.0 CB I:CYS108 3.3 51.1 1.0 CB I:CYS114 3.4 40.0 1.0 N I:CYS114 3.5 46.1 1.0 N I:SER115 3.5 45.3 1.0 N I:CYS108 3.7 54.7 1.0 CA I:CYS114 3.8 43.1 1.0 CA I:CYS108 4.0 50.8 1.0 C I:CYS114 4.0 44.6 1.0 N I:ALA113 4.3 50.3 1.0 N I:THR116 4.3 41.9 1.0 N I:GLU109 4.4 66.6 1.0 CA I:SER115 4.4 39.6 1.0 C I:CYS108 4.5 53.8 1.0 N I:ALA107 4.5 51.2 1.0 OG1 I:THR116 4.5 49.3 1.0 N I:ALA110 4.6 51.7 1.0 N I:LEU112 4.6 56.4 1.0 SG I:CYS117 4.6 49.7 1.0 C I:ALA113 4.6 47.0 1.0 C I:GLY106 4.7 51.2 1.0 CA I:GLY106 4.8 49.1 1.0 N I:CYS117 4.8 40.4 1.0 N I:SER111 4.8 55.4 1.0 C I:ALA107 4.9 55.2 1.0 C I:SER115 4.9 41.2 1.0 CA I:LEU112 5.0 56.9 1.0

Iron binding site 3 out of 4 in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ I:Fe201 b:63.3 occ:1.00 FE2 I:FES201 0.0 63.3 1.0 S1 I:FES201 2.2 43.8 1.0 S2 I:FES201 2.2 44.0 1.0 SG I:CYS154 2.3 57.3 1.0 SG I:CYS117 2.3 49.7 1.0 CB I:CYS154 2.9 40.1 1.0 FE1 I:FES201 3.1 60.6 1.0 CB I:CYS117 3.3 31.7 1.0 N I:CYS154 4.1 44.9 1.0 CA I:CYS154 4.1 40.4 1.0 CA I:ALA110 4.3 50.5 1.0 SG I:CYS108 4.3 64.3 1.0 N I:ALA110 4.4 51.7 1.0 N I:CYS117 4.5 40.4 1.0 CA I:CYS117 4.5 36.1 1.0 CB I:LEU152 4.7 36.3 1.0 N I:LEU112 4.9 56.4 1.0 CD2 I:LEU94 4.9 56.9 1.0 C I:CYS154 4.9 45.9 1.0 CD1 I:LEU152 4.9 38.5 1.0 SG I:CYS114 4.9 51.7 1.0

Iron binding site 4 out of 4 in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Proximal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ H:Fe201 b:134.6 occ:1.00 OD2 H:ASP71 2.1 72.8 1.0 NE2 H:HIS137 2.3 92.7 1.0 SG H:CYS95 2.3 79.0 1.0 SG E:CYS381 2.3 94.8 1.0 CG H:ASP71 3.0 72.8 1.0 CE1 H:HIS137 3.2 91.5 1.0 CD2 H:HIS137 3.3 92.9 1.0 OD1 H:ASP71 3.4 74.5 1.0 CB H:CYS95 3.5 63.7 1.0 CB E:CYS381 3.6 92.4 1.0 SG H:CYS138 3.9 86.1 1.0 SG H:CYS69 3.9 95.4 1.0 NZ H:LYS135 4.1 82.2 1.0 N H:CYS95 4.2 65.0 1.0 CB H:ASP71 4.4 66.5 1.0 ND1 H:HIS137 4.4 90.5 1.0 CG H:HIS137 4.4 92.0 1.0 CA H:CYS95 4.5 61.8 1.0 CB H:ALA98 4.7 58.9 1.0 CA E:CYS381 4.7 94.0 1.0

R.Steinhilper, L.Boss, S.A.Freibert, V.Schulz, N.Krapoth, S.Kaltwasser, R.Lill, B.J.Murphy. Two-Stage Binding of Mitochondrial Ferredoxin-2 to the Core Iron-Sulfur Cluster Assembly Complex. Nat Commun V. 15 10559 2024.
ISSN: ESSN 2041-1723
PubMed: 39632806
DOI: 10.1038/S41467-024-54585-4