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Iron in PDB 1j8u: Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin

Enzymatic activity of Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin

All present enzymatic activity of Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin:
1.14.16.1;

Protein crystallography data

The structure of Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin, PDB code: 1j8u was solved by O.A.Andersen, T.Flatmark, E.Hough, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.50
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 66.441, 108.676, 124.418, 90.00, 90.00, 90.00
R / Rfree (%) 15.4 / 20.3

Iron Binding Sites:

The binding sites of Iron atom in the Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin (pdb code 1j8u). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin, PDB code: 1j8u:

Iron binding site 1 out of 1 in 1j8u

Go back to Iron Binding Sites List in 1j8u
Iron binding site 1 out of 1 in the Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe428

b:18.1
occ:1.00
 OE2 A:GLU330 2.1 23.1 1.0
NE2 A:HIS285 2.1 16.7 1.0
NE2 A:HIS290 2.1 16.2 1.0
O A:HOH1250 2.1 20.5 1.0
O A:HOH1253 2.4 26.1 1.0
O A:HOH1251 2.4 20.0 1.0
CD A:GLU330 3.0 22.9 1.0
CD2 A:HIS290 3.1 15.6 1.0
CE1 A:HIS285 3.1 20.4 1.0
CE1 A:HIS290 3.1 15.2 1.0
CD2 A:HIS285 3.1 14.0 1.0
OE1 A:GLU330 3.1 30.2 1.0
O4 A:H4B429 3.8 25.8 1.0
ND1 A:HIS290 4.2 15.6 1.0
ND1 A:HIS285 4.2 19.2 1.0
CG A:HIS290 4.2 15.7 1.0
CG A:HIS285 4.3 14.6 1.0
OE2 A:GLU286 4.4 15.1 1.0
O A:HOH1108 4.4 29.9 1.0
CG A:GLU330 4.4 17.6 1.0
CB A:ALA345 4.5 13.0 1.0
OH A:TYR325 4.5 18.6 1.0
O A:HOH1327 4.7 35.5 1.0

Reference:

O.A.Andersen, T.Flatmark, E.Hough. High Resolution Crystal Structures of the Catalytic Domain of Human Phenylalanine Hydroxylase in Its Catalytically Active Fe(II) Form and Binary Complex with Tetrahydrobiopterin. J.Mol.Biol. V. 314 279 2001.
ISSN: ISSN 0022-2836
PubMed: 11718561
DOI: 10.1006/JMBI.2001.5061
Page generated: Wed Jul 16 16:29:15 2025

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