Iron in PDB 5z62: Structure of Human Cytochrome C Oxidase

All present enzymatic activity of Structure of Human Cytochrome C Oxidase:
1.9.3.1;

The structure of Structure of Human Cytochrome C Oxidase also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Zinc	(Zn)	1 atom
Copper	(Cu)	3 atoms

The binding sites of Iron atom in the Structure of Human Cytochrome C Oxidase (pdb code 5z62). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Structure of Human Cytochrome C Oxidase, PDB code: 5z62:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Structure of Human Cytochrome C Oxidase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of Human Cytochrome C Oxidase within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe603 b:54.0 occ:1.00 FE A:HEA603 0.0 54.0 1.0 NA A:HEA603 2.0 54.0 1.0 NC A:HEA603 2.1 54.0 1.0 NB A:HEA603 2.1 54.0 1.0 ND A:HEA603 2.1 54.0 1.0 NE2 A:HIS378 2.6 51.5 1.0 NE2 A:HIS61 2.7 54.7 1.0 C1A A:HEA603 3.0 54.0 1.0 C4A A:HEA603 3.0 54.0 1.0 CD2 A:HIS61 3.0 54.7 1.0 C1D A:HEA603 3.1 54.0 1.0 C4C A:HEA603 3.1 54.0 1.0 C1C A:HEA603 3.1 54.0 1.0 C1B A:HEA603 3.1 54.0 1.0 C4B A:HEA603 3.1 54.0 1.0 C4D A:HEA603 3.1 54.0 1.0 CD2 A:HIS378 3.3 51.5 1.0 CHA A:HEA603 3.4 54.0 1.0 CHB A:HEA603 3.5 54.0 1.0 CHC A:HEA603 3.5 54.0 1.0 CHD A:HEA603 3.5 54.0 1.0 CE1 A:HIS378 3.8 51.5 1.0 CE1 A:HIS61 3.9 54.7 1.0 C3A A:HEA603 4.2 54.0 1.0 C2A A:HEA603 4.2 54.0 1.0 CG A:HIS61 4.4 54.7 1.0 C3C A:HEA603 4.4 54.0 1.0 C2D A:HEA603 4.4 54.0 1.0 C2B A:HEA603 4.4 54.0 1.0 C2C A:HEA603 4.5 54.0 1.0 C3B A:HEA603 4.5 54.0 1.0 C3D A:HEA603 4.5 54.0 1.0 CG A:HIS378 4.6 51.5 1.0 ND1 A:HIS61 4.7 54.7 1.0 ND1 A:HIS378 4.8 51.5 1.0

Iron binding site 2 out of 2 in the Structure of Human Cytochrome C Oxidase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Structure of Human Cytochrome C Oxidase within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe604 b:58.4 occ:1.00 FE A:HEA604 0.0 58.4 1.0 NA A:HEA604 2.0 58.4 1.0 NC A:HEA604 2.1 58.4 1.0 ND A:HEA604 2.1 58.4 1.0 NB A:HEA604 2.1 58.4 1.0 NE2 A:HIS376 2.8 54.3 1.0 C4A A:HEA604 3.0 58.4 1.0 C1A A:HEA604 3.0 58.4 1.0 C1C A:HEA604 3.1 58.4 1.0 C4C A:HEA604 3.1 58.4 1.0 C1B A:HEA604 3.1 58.4 1.0 C1D A:HEA604 3.1 58.4 1.0 C4D A:HEA604 3.1 58.4 1.0 C4B A:HEA604 3.1 58.4 1.0 CD2 A:HIS376 3.4 54.3 1.0 CHB A:HEA604 3.4 58.4 1.0 CHA A:HEA604 3.5 58.4 1.0 CHD A:HEA604 3.5 58.4 1.0 CHC A:HEA604 3.5 58.4 1.0 CE1 A:HIS376 3.9 54.3 1.0 C3A A:HEA604 4.2 58.4 1.0 C2A A:HEA604 4.2 58.4 1.0 C3C A:HEA604 4.4 58.4 1.0 C2C A:HEA604 4.4 58.4 1.0 C2B A:HEA604 4.5 58.4 1.0 C2D A:HEA604 4.5 58.4 1.0 C3D A:HEA604 4.5 58.4 1.0 C3B A:HEA604 4.5 58.4 1.0 CU A:CU601 4.5 65.3 1.0 CG A:HIS376 4.7 54.3 1.0 CE1 A:HIS240 4.9 62.3 1.0 ND1 A:HIS376 4.9 54.3 1.0

S.Zong, M.Wu, J.Gu, T.Liu, R.Guo, M.Yang. Structure of the Intact 14-Subunit Human Cytochrome C Oxidase. Cell Res. V. 28 1026 2018.
ISSN: ISSN 1748-7838
PubMed: 30030519
DOI: 10.1038/S41422-018-0071-1